Evidence map›Paper›PMID 42434536›Full record

ArticleClinical case reports2026

Hemodynamic Unmasking of Atrial Septal Defect After Pulmonary Arterial Hypertension Therapy: A Pathophysiologic Perspective.

Nwachukwu O Nwachukwu, Chukwuka Elendu, Chimaobi Nwevo, Davidson J Ozoemena, Emmanuel O Ikechukwu, Nwamaka C Bob-Ume, Ebiere S Kalama

Abstract readLetter
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nwachukwu O NwachukwuDarlington Memorial Hospital Darlington UK.
Chukwuka ElenduFederal University Teaching Hospital Owerri Nigeria.ORCID https://orcid.org/0000-0002-0249-1865
Chimaobi NwevoNYC Health + Hospitals/South Brooklyn Health Brooklyn New York USA.
Davidson J OzoemenaWayne State University Detroit Michigan USA.
Emmanuel O IkechukwuEnugu State University of Science and Technology Enugu Nigeria.
Nwamaka C Bob-UmeAll Saints University College of Medicine Kingstown Saint Vincent and the Grenadines.
Ebiere S KalamaNiger Delta University Amassoma Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary arterial hypertension may mask underlying atrial septal defects by reducing left-to-right shunt flow through elevated pulmonary vascular resistance and impaired right ventricular compliance. Targeted therapy may unmask latent defects, emphasizing early multimodality imaging and sustained clinical suspicion for congenital shunts when invasive hemodynamic assessment suggests shunting despite inconclusive echocardiography.

Indexed as

atrial septal defecthemodynamic unmaskingmultimodality cardiac imagingpulmonary arterial hypertensionright ventricular compliance

Identifiers

PMID42434536
PMCPMC13351921

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.