ArticleACS materials Au2026
Patient-Specific Dual-Function 3D-Printed Gels for Antimicrobial and Analgesic Management of Alveolar Osteitis.
Article in ACS materials Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alveolar osteitis (AO), or dry socket, is a painful postoperative complication caused by the premature loss of the blood clot from the extraction site. Current treatments rely on irrigation and temporary dressings, however these approaches offer limited therapeutic benefits and often require repeated interventions. This work describes a customizable, dual-function biomaterials platform based on 3D-printed gelatin gels incorporating the antimicrobial quaternary ammonium compound, benzyldimethyldodecylammonium (BDMDAC), and the analgesic lidocaine enabling sustained infection control and localized pain management. 3D-printed gels were optimized for printability, mechanical stability, and controlled drug release, and their physicochemical properties were characterized through swelling, degradation, and release studies. Both hydrated and freeze-dried gels were evaluated to assess how architecture influences transport behavior and therapeutic performance. Antimicrobial efficacy was evaluated against clinically relevant oral pathogens, including
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