Evidence map›Paper›PMID 42434425›Full record

ArticleFrontiers in cellular and infection microbiology2026

Sex-specific signatures of gut microbiota and systemic inflammation in patients with urolithiasis: a cross-sectional study.

Hao Chen, Fengyi Tian, Shuqing Sheng, Mingrui Wang, Xiangcheng Zhan, Yuchen Gao, Bowen Chen, Yunze Dong, Shuai Liu, Yanhua Chen and 4 more

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Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Hao Chen *Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Fengyi Tian *Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Shuqing Sheng *Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Mingrui WangDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiangcheng ZhanDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yuchen GaoDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Bowen ChenDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yunze DongDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Shuai LiuDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yanhua ChenDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Xudong YaoDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Tiancheng XieDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhuifeng GuoDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, China.
Yunfei XuDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Urolithiasis is a globally prevalent disease with a distinct male predominance; however, the pathophysiological heterogeneity within diagnosed cohorts remains underexplored. This study delineates the sex-specific signatures of gut microbiota and systemic inflammation in urolithiasis patients to inform sex-stratified management. Methods: This cross-sectional study enrolled 60 urolithiasis patients (40 males, 20 females). Systemic inflammatory cytokines were quantified via peripheral blood assays, and gut microbiota was profiled using 16S rRNA sequencing. Data were integrated to evaluate microbiome-immune-metabolic associations. Results: Baseline demographics and routine biochemical parameters were comparable between sexes. Male patients exhibited significantly elevated peripheral levels of pro-inflammatory cytokines, including IL-5, IL-17A, IFN-α, IL-12P70, and IFN-γ (P < 0.05). Beta-diversity analysis revealed no significant difference in the overall gut microbial community structures between sexes (P = 0.484). LEfSe analysis identified a significant enrichment of Conclusion: Our findings highlight significant sex-associated differences in gut microecology and systemic immune profiles within urolithiasis patients. The proinflammatory axis associated with male patients and the enhanced predicted metabolic capacities observed in female patients emphasize the potential value of exploring sex-tailored preventive and therapeutic interventions.

Indexed as

Gastrointestinal MicrobiomeInflammationUrolithiasisAdultAgedBacteriaCross-Sectional StudiesCytokinesFemaleHumansInterleukin-17MaleMiddle AgedRNA, Ribosomal, 16SSex FactorsCytokinesInterleukin-17RNA, Ribosomal, 16S16S rRNAdisease phenotypinggut microbiomesex differencessystemic inflammationurolithiasis

Identifiers

PMID42434425
PMCPMC13350461

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.