Effects of hesperidin supplementation on inflammation and oxidative stress in overweight or obese individuals: a systematic review and meta-analysis of randomized controlled trials.

Kun Zhu, Wen Li, Tingting Liao, Jianlong Guo, Tingwei Huang, Degui Chang, Yaodong You

Abstract readReview

In one paragraph

Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kun Zhu *Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Wen Li *Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Tingting LiaoHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Jianlong GuoHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Tingwei HuangHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Degui ChangHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Yaodong You *Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate, through a systematic review and meta-analysis of randomized controlled trials (RCTs), the effects of hesperidin and hesperidin-containing citrus interventions on biomarkers of inflammation, oxidative stress, and endothelial function in overweight or obese individuals. Two authors independently searched PubMed, Web of Science, Embase, Scopus, and the Cochrane Library from inception to April 4, 2026. Methodological quality was assessed using the Cochrane Risk of Bias 2 tool (RoB 2), and certainty of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Heterogeneity was assessed using Cochran's

Indexed as

citrus matrixhesperidininflammationmeta-analysisobesityoverweightoxidative stress

Identifiers

PMID42434414

DOI10.3389/fnut.2026.1871474

PMCPMC13350032

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.