ArticleFrontiers in nutrition2026
Associations of maternal pre-pregnancy body mass index with pregnancy complications and infant adiposity at 6 months corrected age: a two-center retrospective cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To assess associations of maternal pre-pregnancy BMI with pregnancy complications, adverse perinatal outcomes, and infant adiposity at 6 months corrected age. Methods: This two-center retrospective cohort included 707 mother-infant dyads from 790 eligible pregnancies between March 2021 and June 2023. Pre-pregnancy BMI was classified as underweight (<18.5 kg/m Results: Among 707 women, 47 (6.6%) were underweight, 314 (44.4%) normal-weight, 220 (31.1%) overweight, and 126 (17.8%) obese. Higher BMI category was associated with higher HbA1c, gestational diabetes mellitus, gestational hypertensive disorders, postpartum hemorrhage, macrosomia, NICU admission, and infant adiposity z-scores. Compared with normal weight, overweight (adjusted OR 1.38, 95% CI 1.01-1.90) and obesity (adjusted OR 1.86, 95% CI 1.24-2.78) were associated with higher odds of adverse perinatal outcomes. Maternal obesity was associated with higher odds of infant obesity at 6 months corrected age (adjusted OR 2.23, 95% CI 1.18-4.20), whereas breastfeeding was associated with lower odds (adjusted OR 0.65, 95% CI 0.39-0.94). Conclusion: Maternal pre-pregnancy overweight and obesity were associated with pregnancy complications, adverse perinatal outcomes, and increased infant adiposity at 6 months corrected age. Preconception weight management and breastfeeding support may help reduce early metabolic risk.
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