Evidence map›Paper›PMID 42434398›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Investigating the foreign body response and regenerative mechanisms in medical-grade polycaprolactone scaffold guided breast reconstruction in a porcine model.

Leopold Klein, Ronja Finze, Jan Janzekovic, Matthew Cheng, Siamak Saifzadeh, Owen Ung, Michael Wagels, Dietmar W Hutmacher, Flavia Medeiros Savi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leopold KleinDepartment for Medical Technologies and Regenerative Medicine, Institute of Biomedical Engineering, Eberhard Karls University Tübingen, Tübingen, Germany.
Ronja FinzeCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD, Australia.
Jan JanzekovicCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD, Australia.
Matthew ChengCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD, Australia.
Siamak SaifzadehCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD, Australia.
Owen UngMNHHS Comprehensive Breast Cancer Institute, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.
Michael WagelsCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD, Australia.
Dietmar W Hutmacher *Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD, Australia.
Flavia Medeiros Savi *Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To enhance the clinical use of scaffold-guided breast reconstruction (SGBR), the porcine model provides a reliable means of assessing scaffold biocompatibility and tissue regeneration. Understanding the immunological processes triggered by the implantation of medical-grade polycaprolactone (mPCL) scaffolds is essential for elucidating the underlying biology and optimizing the regenerative potential of tissue engineering and regenerative medicine (TE&RM) technologies. This observational work aims to characterize these

Indexed as

3D printingbiocompatibilitybreast reconstructionIHCpolycaprolactoneporcine modelscaffold guided tissue regeneration

Identifiers

PMID42434398
PMCPMC13351527

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.