Evidence map›Paper›PMID 42434335›Full record

ArticleJournal of pharmaceutical analysis2026

Discovery and optimization of a novel non-nitrocatechol COMT inhibitor for modulating levodopa metabolism.

Rong Zhu, Pu Wang, Sheng-Lan Qi, Yu Zhang, Chun-Lan Xie, Ya Yang, Cong Hu, Zi-Qiong Zhou, Dong-Fang Zhao, Chao Yang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rong ZhuHainan Academy of Medical Sciences, Hainan Medical University, Haikou, 571199, China.
Pu WangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Sheng-Lan QiState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Yu ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Chun-Lan XieHainan Academy of Medical Sciences, Hainan Medical University, Haikou, 571199, China.
Ya YangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Cong HuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Zi-Qiong ZhouState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Dong-Fang ZhaoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Chao YangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Jie SunSchool of Chemical Engineering, Ocean and Life Sciences, Dalian University of Technology, Panjin, Liaoning, 124221, China.
Xian-Wen YangHainan Academy of Medical Sciences, Hainan Medical University, Haikou, 571199, China.
Guang-Bo GeState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Ping WangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human catechol-

Indexed as

Catechol-O-methyltransferase (COMT)Drugability optimizationFlavonoidsStructure-activity relationship (SAR)Visualization screening

Identifiers

PMID42434335
PMCPMC13352008

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.