Evidence map›Paper›PMID 42434332›Full record

ArticleJournal of pharmaceutical analysis2026

Elucidation of ACAT1's role in hepatic ischemia-reperfusion injury: TFEB-mediated mitophagy and ferroptosis modulation as therapeutic targets.

Xiangwei Li, Ting Xu, Shaochuang Wang, Long Ma, Xiangyou Yu, Yi Wang, Linlin Bai, Jun Cao, Zuyi Zhao, Meiting Du and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiangwei LiDepartment of Gastrointestinal Surgery, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, China.
Ting XuHematology Research Laboratory, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, China.
Shaochuang WangDepartment of Hepatobiliary Surgery, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, China.
Long MaDepartment of Critical Care Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Xiangyou YuDepartment of Critical Care Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Yi WangDepartment of Critical Care Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Linlin BaiDepartment of Critical Care Medicine, Shenzhen People's Hospital, Shenzhen, Guangdong, 518020, China.
Jun CaoState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi, 830054, China.
Zuyi ZhaoDepartment of Critical Care Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Meiting DuDepartment of Critical Care Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
Hao WenState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi, 830054, China.
Kun WuDepartment of Gastrointestinal Surgery, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic ischemia-reperfusion injury (HIRI) remains a critical clinical challenge, significantly impacting the success of liver transplantation and postoperative recovery following resection. The study investigated the roles of mitochondrial acetyl-CoA acetyltransferase1 (ACAT1) and transcription factor EB (TFEB) in orchestrating cellular responses to HIRI, specifically focusing on mitophagy and ferroptosis pathways. Using a combination of

Indexed as

Acetyl-CoA acetyltransferase 1AcetylproteomicsHepatic ischemia reperfusion injurySingle-cell transcriptomicsTranscription factor EB

Identifiers

PMID42434332
PMCPMC13352073

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.