ArticleJournal of gastrointestinal oncology2026
Single-cell transcriptomics reveals the prognostic and immune infiltration significance of FOLFOX-bevacizumab treatment and lysine crotonylation characteristics in colon cancer.
Article in Journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Colon cancer (CC), a malignant tumor originating from the colonic mucosal epithelium, frequently exhibits limited efficacy in advanced patients undergoing first-line FOLFOX (oxaliplatin, leucovorin, and 5-fluorouracil)-bevacizumab (FOLFOX-Bev) therapy due to resistance. Lysine crotonylation (Kcr), a novel histone post-translational modification, regulates gene transcription and participates in processes such as cell proliferation, metabolic reprogramming, and epithelial-mesenchymal transition, presenting potential research value in CC. However, its impact on FOLFOX-Bev treatment response and immune microenvironment remodeling at the single-cell level remains unclear. Therefore, this study aimed to integrate single-cell transcriptomics with The Cancer Genome Atlas (TCGA) data to systematically characterize the role of Kcr modification in FOLFOX-Bev treatment response and immune microenvironment remodeling in CC, and to construct a Kcr-based prognostic risk model for guiding precision therapy. Methods: This study integrated single-cell transcriptome with TCGA CC data [colon adenocarcinoma (COAD)]. Malignant cells were identified using Inference of Copy Number Variations and were stratified into high/low groups based on area under the curve cell-level enrichment analysis scores calculated for a Kcr-related gene set. Differential analysis and cell communication studies were performed. Sensitive/resistant malignant subpopulations were distinguished based on pre-/post-treatment changes, and their Kcr scores were compared to screen differentially expressed genes (DEGs) between "sensitive & high- Kcr" Results: Focusing on "sensitive & high-Kcr" Conclusions: This study is the first to reveal, at single-cell resolution, that Kcr modification drives FOLFOX-Bev resistance in CC by reshaping the immune microenvironment. The prognostic model, based on key genes (
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