ArticleJournal of gastrointestinal oncology2026
Clinicopathological and molecular profiling of sporadic synchronous multiple primary colorectal cancers: focus on microsatellite instability status.
Article in Journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sporadic synchronous multiple primary colorectal cancer (SSCRC) is uncommon, and its molecular features remain unclear. This study aimed to compare the clinicopathological and molecular characteristics of SSCRC with solitary colorectal cancer and to evaluate microsatellite instability (MSI) status across synchronous lesions. Methods: We retrospectively enrolled 46 patients with synchronous CRCs and 202 patients with solitary CRCs. MSI status was determined for each SSCRC lesion using polymerase chain reaction (PCR)-based testing. Additional clinicopathological variables and selected molecular features were also assessed. Results: Compared with solitary CRC, SSCRC index lesions were associated with more advanced clinicopathological features (all P<0.05). The proportion of deficient mismatch repair (dMMR) was significantly higher in SSCRC (19.6% Conclusions: MSI status appears central to SSCRC biology and may aid prognostic stratification. SSCRC exhibits distinct clinicopathological and molecular characteristics relative to solitary CRC, supporting the need for lesion-level molecular evaluation to inform personalized management. In particular, patients with dMMR tumors may benefit from immunotherapy, highlighting the clinical importance of MSI assessment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.