ReviewJournal of clinical and experimental dentistry2026
Use of epinephrine combined with dental anesthetics in hypertensive patients during dental treatment.
Review in Journal of clinical and experimental dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Background: The use of local anesthetics containing epinephrine is routine in dental practice, although concerns persist regarding their safety in patients with cardiovascular disease. Material and Methods: This prospective study was designed to evaluate the effects of 2 percent mepivacaine with 1:100,000 epinephrine on hemodynamic stability in individuals with con-trolled hypertension. Sixty-five individuals aged 20 to 60 years were monitored using automated blood pressure and pulse oximetry devices before anesthesia (t0'), five minutes following injection (t5), and thirty minutes after administration (t30). Systolic and diastolic blood pressure, heart rate, and oxygen saturation were assessed. Results: No significant alterations were detected at any time point in either hypertensive or normotensive subjects. Conclusions: Epinephrine at a 1:100,000 concentration combined with 2 percent mepivacaine does not compromise short-term hemodynamic stability in patients with controlled hypertension undergoing routine dental extractions.
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