ReviewJournal of clinical and experimental dentistry2026
Effect of Pre-emptive Injection-based Corticosteroid Administration and Its Routes on Post-Endodontic Pain: A Systematic Review and Meta-analysis of Randomized Clinical Trials.
Review in Journal of clinical and experimental dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Post-endodontic pain PP is a frequent complication following root canal treatment RCT, primarily resulting from acute inflammation. Pre-emptive corticosteroid administration has been proposed to attenuate this inflammatory response and reduce PP. This systematic review and meta-analysis assessed the effectiveness of injection-based corticosteroids delivered through different routes in minimizing PP at various postoperative intervals. Material and Methods: A comprehensive search of PubMed, Scopus, Web of Science, LILACS, Cochrane Library, and Google Scholar was conducted up to March 2025, following PRISMA 2020 guidelines. Randomized controlled trials evaluating pre-emptive corticosteroid injections via infiltrative, intraligamentary, or intramuscular routes were included. Risk of bias was assessed using the Cochrane RoB 2.0 tool, and meta-analyses were performed using Review Manager 5.4. The review was prospectively registered in PROSPERO CRD420251005886. Results: Nine RCTs comprising 917 participants were analyzed. Corticosteroid injections, including dexamethasone, methylprednisolone, and betamethasone, significantly reduced PP compared with placebo at all time points, with the most pronounced effect within the first 12 hours and sustained, though reduced, benefits up to 72 hours. Infiltrative injections demonstrated greater efficacy than intraligamentary routes. Conclusions: Pre-emptive corticosteroid injections, particularly dexamethasone via infiltrative or intraligamentary routes, effectively reduce post-endodontic pain, especially within the first 24 hours.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.