ArticleInternational journal of preventive medicine2026
The Effectiveness of Topical Gel Containing Arginine-Releasing Chitosan Nanofibers on the Healing of Diabetic Foot Ulcers: A Randomized Controlled Clinical Trial.
Article in International journal of preventive medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diabetic foot ulcer (DFU) is one of serious consequences of diabetes mellitus leading to many complications. Chitosan is a natural polymer used in wound dressings and is effective on healing. Also, arginine is the most important amino acid in wound healing. In this study, the clinical effects of a topical gel containing arginine-releasing chitosan nanofibers on the healing of DFUs was evaluated. Methods: In this randomized controlled clinical trial, patients with grades 1 or 2 DFU were divided to two groups of drug ( Results: There was significant decrease in the wound size in both groups at the end of weeks 1 and 2 compared to the baseline. However, there was no significant difference between the groups regarding the percentage of decrease in the size. There was no significant difference between the groups in terms of the rate of complete wound healing at the end of the study (9 cases [36%] vs. 7 cases [22.58%], respectively; Conclusions: Topical gel containing arginine-releasing chitosan nanofibers improves and accelerates the healing of DFUs. However, more studies are required to confirm these effects.
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