Trial reportFrontiers in neurology
Combination of Yaobitong capsules and lumbar oblique pull manipulation for moderate pain in lumbar disc herniation with radiculopathy: a multicenter, randomized, three-arm, parallel-group controlled trial.
Trial report in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
28 authors.
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Abstract
Background: Lumbar disc herniation with radiculopathy (LDHR) is a leading cause of disability worldwide. For patients with moderate pain, Traditional Chinese Medicine approaches, including Yaobitong (YBT) capsules and lumbar oblique pull manipulation (LOPM), are widely used in clinical practice, often in combination. However, high-quality evidence supporting the superiority of this combination over monotherapy is lacking. This multicenter, randomized, three-arm, parallel-group controlled trial conducted at 13 tertiary hospitals in China aimed to evaluate the efficacy and safety of combining YBT with LOPM in LDHR patients with moderate pain. Methods: A total of 426 LDHR patients with moderate pain (Visual Analogue Scale [VAS] score ≥ 4 to < 7) were randomly assigned to receive either YBT alone ( Results: At 2 weeks, the mean reduction in ODI was -19.4 (95% CI, -21.4 to -17.5) in the YBT group, -19.4 (95% CI, -21.4 to -17.5) in the LOPM group, and -21.1 (95% CI, -23.0 to -19.1) in the combination group. The adjusted mean difference was 0.5 (95% CI, -2.3 to 4.9; Conclusion: The combination therapy with YBT and LOPM was not superior to either monotherapy in improving functional disability, pain, or quality of life among LDHR patients with moderate pain. Clinical trial registration: https://www.chictr.org.cn, ChiCTR2200066051.
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