Evidence map›Paper›PMID 42434017›Full record

ArticleRespiratory medicine case reports2026

Pulmonary coexistence of immunoglobulin light chain amyloidosis and light chain deposition disease: A case report.

Yasushi Murakami, Makoto Goshima, Mitsuki Tanimoto, Naoto Kobayashi, Atsushi Sumida, Reo Kondo, Shoichi Mori, Ayami Kiriyama, Hideki Murakami, Kai Miyazaki and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yasushi MurakamiDepartment of Respiratory Medicine, Tsushima City Hospital, Tsushima, Aichi, Japan.
Makoto GoshimaDepartment of Respiratory Medicine, Tsushima City Hospital, Tsushima, Aichi, Japan.
Mitsuki TanimotoDepartment of Respiratory Medicine, Tsushima City Hospital, Tsushima, Aichi, Japan.
Naoto KobayashiDepartment of Respiratory Medicine, Tsushima City Hospital, Tsushima, Aichi, Japan.
Atsushi SumidaDepartment of Respiratory Medicine, Tsushima City Hospital, Tsushima, Aichi, Japan.
Reo KondoDepartment of Thoracic Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Aichi, Japan.
Shoichi MoriDepartment of Thoracic Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Aichi, Japan.
Ayami KiriyamaDepartment of Pathology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Aichi, Japan.
Hideki MurakamiDepartment of Pathology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Aichi, Japan.
Kai MiyazakiDepartment of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, Japan.
Yukako Shintani-DomotoDepartment of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the case of a 73-year-old woman with diffuse pulmonary cysts and multiple nodules incidentally detected during the follow-up for chronic liver disease. High-resolution computed tomography revealed numerous thin-walled cysts, predominantly in the lower lobes, with randomly distributed nodules. Pathological evaluation of the surgical lung biopsy specimens revealed nodular deposits of eosinophilic, amorphous material with peribronchiolar lymphoplasmacytic inflammation and identified pulmonary mucosa-associated lymphoid tissue lymphoma. Congo red staining revealed coexisting positive and negative foci within a single nodule, whereas immunohistochemistry showed kappa (κ) light chain positivity in both. Laser microdissection with liquid chromatography-tandem mass spectrometry identified a κ light chain dominant signature with amyloid signature proteins in the Congo red-positive region, consistent with immunoglobulin light chain amyloidosis (AL) κ-type, and abundant κ light chain peptides without amyloid signature proteins in the Congo red-negative region, consistent with non-amyloid κ light chain deposition. Systemic evaluation revealed no extrapulmonary amyloid or light-chain deposition, whereas Sjögren disease was confirmed by serological testing and minor salivary gland histology. The patient was managed conservatively with surveillance and remained clinically and radiographically stable without disease progression for approximately 1 year. Pulmonary AL and light-chain deposition are rare lung disorders, and pathologically proven pulmonary coexistence is rare. This case may help delineate the clinicopathological features of pulmonary monoclonal light chain deposition disorders.

Indexed as

Diffuse cystic lung diseaseImmunoglobulin light chain amyloidosisLaser microdissection followed by liquid chromatography-tandem mass spectrometryLight chain deposition diseaseMucosa-associated lymphoid tissue lymphomaSjögren disease

Identifiers

PMID42434017
PMCPMC13351146

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