ArticleFrontiers in medicine2026
Peak-MELD scores, a disease trajectory associated with reduced access to liver transplantation.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The Model for End-Stage Liver Disease (MELD) score has been the primary allocation tool in the Eurotransplant region. However, certain patient groups remain disadvantaged. As diagnostic and therapeutic means evolve, regular revision of allocation criteria is necessary. Infectious diseases can lead to acute organ dysfunction and transient increases in MELD scores, whereas uncontrolled infections represent a contraindication to transplantation. In this retrospective study, we investigated peak-MELD scores, defined as a transient increase of at least five MELD points within 1 month, and evaluated their association with infections and liver transplantation outcomes. Among 109 patients listed for liver transplantation at LMU University Hospital between 2019 and 2022, 11% experienced a peak-MELD trajectory. It was associated with a significantly lower transplantation rate independent of baseline characteristics (HR = 0.37; 95% CI [0.15, 0.92];
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