ArticleFrontiers in medicine2026
Misdiagnosis analysis and multidisciplinary collaborative treatment of primary cutaneous diffuse large B-cell lymphoma: case report.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Primary cutaneous diffuse large B-cell lymphoma (PC-DLBCL) is a rare subtype of non-Hodgkin lymphoma with nonspecific cutaneous manifestations, leading to frequent misdiagnosis. This case describes an elderly patient with severe ulcerative skin lesions who was misdiagnosed repeatedly and required multidisciplinary orthopedic-hematologic management, thus providing valuable evidence for clinical practice. An 85-year-old male presented with progressive erythematous papules, ulcers, and subcutaneous nodules on the right forearm, chest, back, and left upper arm. Pathology and immunohistochemistry confirmed primary cutaneous diffuse large B-cell lymphoma. He underwent orthopedic debridement, autologous skin grafting, and 4 cycles of R-miniCHOP immunochemotherapy. Skin lesions resolved completely without recurrence, and 7-month follow-up showed favorable recovery. The key take-away is that PC-DLBCL is often misdiagnosed; early pathological biopsy and multidisciplinary collaboration between orthopedics and hematology-oncology are essential for accurate diagnosis and effective treatment to improve prognosis in elderly patients.
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