ReviewTranslational pediatrics2026
Maternal-fetal transmission of Zika virus and long-term neurodevelopmental outcomes in children: a narrative review.
Review in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: The Zika virus (ZIKV), a flavivirus transmitted through mosquito bites, presents significant global health challenges due to its potential to cause severe congenital malformations, particularly neurological disorders. It is imperative to comprehend the transmission pathways and the long- term impact of ZIKV on children's neurodevelopment. This narrative review aims to summarize current evidence on maternal-fetal transmission of ZIKV and its neurodevelopmental consequences in offspring. Methods: A narrative review with systematic elements was conducted using PubMed, Scopus, and Web of Science [2015-2024]. Relevant studies on ZIKV vertical transmission and neurodevelopmental outcomes were screened, with independent data extraction and quality assessment performed by multiple reviewers. Key Content and Findings: Twenty-one studies with diverse designs met the inclusion criteria. The research suggests that human decidual cells facilitate the transmission of ZIKV, a virus specific to the fetus, primarily infecting the fetus during the first trimester via the placenta. Congenital Zika syndrome (CZS) was prevalent, characterized by ocular and joint abnormalities, cerebral atrophy, and microcephaly. Children born without microcephaly also exhibited impaired cognitive, motor, and linguistic development later in life. Other neurological manifestations included Guillain-Barré syndrome, encephalitis, and seizures. Conclusions: Maternal-fetal transmission of ZIKV, particularly during the early stages of pregnancy, results in various long-term neurodevelopmental abnormalities in children. Enhancing outcomes necessitates multimodal therapies, early detection, and routine neurodevelopmental follow-up. Further research is essential to elucidate the underlying mechanisms and improve prevention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.