ArticleTranslational pediatrics2026
Procalcitonin in predicting acute kidney damage in children with initial febrile urinary tract infection: a retrospective study.
Article in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Urinary tract infection (UTI) is the most common bacterial infection in children, with 10-15% progressing to irreversible renal scarring. This study evaluated the predictive value of inflammatory markers for acute renal damage in children with first febrile UTI. Methods: This study conducted a retrospective analysis of 143 children with initial febrile UTI who underwent technetium-99m labelled dimercaptosuccinic acid ( Results: Univariate regression analysis revealed significant associations between acute kidney damage and CRP, absolute neutrophil count, and PCT. Multivariate regression identified both CRP [odds ratio (OR) 1.013, 95% confidence interval (CI): 1.003-1.024, P=0.02] and PCT (OR 1.671, 95% CI: 1.066-2.621, P=0.03) as independent predictors, with area under the curve (AUC) values of 0.718 and 0.815, respectively. Notably, a PCT cutoff >0.26 ng/mL demonstrated superior predictive value (sensitivity 87.1%, specificity 69.0%) compared to other markers. Conclusions: Early measurement of inflammatory markers, particularly PCT, have significant predictive value for acute kidney damage in pediatric febrile UTI. While both PCT and CRP serve as reliable predictors, PCT demonstrates superior diagnostic accuracy, providing a new method to identify early kidney damage in children presenting with first febrile UTI for primary hospitals without single photon emission computer scanner or gamma camera.
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