ArticleAnnals of medicine and surgery (2012)2026
Efficacy of tranexamic acid with/without drain in knee arthroplasty: a randomized prospective clinical study from Northwest Syria.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Purpose: This study evaluated the outcomes of intra-articular tranexamic acid (TXA) and/or suction drainage in patients undergoing total knee arthroplasty (TKA). Materials and Methods: Following approval from the institutional review board, a prospective, randomized, and blinded clinical study was conducted in Northwest Syria, including 192 patients who underwent unilateral TKA between August 2023 and April 2025. Patients were randomly assigned to three groups: TXA with suction drainage, TXA only, or suction drainage only. Patients with coagulopathies, active infections, previous knee surgeries, or contraindications to TXA were excluded. All procedures followed a standardized surgical and postoperative protocol. Outcome measures included total and hidden blood loss (HBL), drainage volume, transfusion rate, limb swelling, and wound complications. Results: Total blood loss was lowest in Group 2 (710 mL) compared to Group 1 (891 mL) and Group 3 (1391 mL) ( Conclusion: Intra-articular TXA without suction drainage appears to be the safest and most effective method to reduce perioperative blood loss in TKA. Larger multicenter studies are recommended.
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