Chromophobe renal cell carcinoma with nodal involvement: A rare case report highlighting unusual molecular features.

Sam Kwon, Tali Newman, Fiona Wardrop, Katherine Zhong, Josiah Dallmer, Andrew Hall, Michael Whalen

Abstract readCase Reports

In one paragraph

Article in Urology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sam KwonThe George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Tali NewmanThe George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Fiona WardropThe George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Katherine ZhongThe George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Josiah DallmerThe George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Andrew HallDepartment of Pathology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Michael WhalenDepartment of Urology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromophobe renal cell carcinoma (ChRCC) is a renal malignancy typically associated with indolent behavior, with nodal involvement being rare. We report a 78-year-old African American male with incidentally discovered node-positive (pN+) ChRCC with sarcomatoid differentiation who developed spinal metastases despite adjuvant pembrolizumab. Histopathologic evaluation demonstrated distinct plant-like cell membranes, while genomic profiling revealed CDK4 amplification and MTAP and CDKN2A alterations associated with aggressive tumor biology. Notably, the tumor also exhibited additional unique molecular alterations that have not been previously reported in the literature.

Indexed as

Chromophobe renal cell carcinomaMutationNeoplasm metastasisSarcomatoid renal cell carcinoma

Identifiers

PMID42433736

DOI10.1016/j.eucr.2026.103527

PMCPMC13351630

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