ArticleFrontiers in veterinary science2026
A targeted PCR approach for the detection of IOLA in canine infectious respiratory disease samples during an atypical CIRD outbreak in winter 2023.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: During winter 2023, an atypical canine infectious respiratory disease (aCIRD) outbreak was associated with high case-fatality rates and poor antibiotic response. Preliminary metagenomics investigations claimed partial sequences resembling Infectious Organism Lurking in Human Airways (IOLA), a poorly characterized bacterium first described in humans, in canine respiratory samples. However, its detectability remained uncertain and required systematic molecular investigation. Methods: We screened 777 veterinarian-submitted canine respiratory samples from the United States using Results: Of the 777 samples screened, 55 contained sequencing reads classified as Rickettsiales. Forty-five of the 55 samples were negative by Conclusion: Dual-target PCR identified no evidence of IOLA in respiratory samples from the 2023 aCIRD outbreak. Non-specific amplification in the
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