Evidence map›Paper›PMID 42433665›Full record

ArticleiScience2026

Highly efficient and low-mosaicism

Eiichi Okamura, Shoma Matsumoto, Eiji Mizutani, Kazuya Murata, Yoko Tanimoto, Tra Thi Huong Dinh, Hayate Suzuki, Akihiro Kuno, Woojin Kang, Natsuki Mikami and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Eiichi OkamuraDepartment of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Shiga, Japan.
Shoma MatsumotoDepartment of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Shiga, Japan.
Eiji MizutaniLaboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Kazuya MurataLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Yoko TanimotoLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Tra Thi Huong DinhLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Hayate SuzukiLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Akihiro KunoLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Woojin KangLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Natsuki MikamiLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Tomoka EmaLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Kento MorimotoResearch Fellow of the Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo, Japan.
Kanako KatoLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Tomoko MatsumotoDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan.
Nanami MasuyamaSchool of Biomedical Engineering, Faculty of Applied Science and Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Yusuke KijimaSchool of Biomedical Engineering, Faculty of Applied Science and Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Genta NagaeGenome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan.
Masanaga MutoDepartment of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Shiga, Japan.
Toshifumi MorimuraDepartment of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Shiga, Japan.
Hideto MoriPremium Research Institute for Human Metaverse Medicine (WPI-PRIMe), The University of Osaka, Suita, Osaka, Japan.
Fumihiro SugiyamaLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Satoru TakahashiLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Hiroyuki AburataniGenome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan.
Knut WoltjenDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan.
Nozomu YachieSchool of Biomedical Engineering, Faculty of Applied Science and Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Seiya MizunoLaboratory Animal Resource Center, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Masatsugu EmaDepartment of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Shiga, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although pronuclear microinjection is the most widely used method for producing transgenic (Tg) animals, phenotypic characterization is usually performed from the next generation onwards because the production efficiency is limited. Conventional Cre-

Indexed as

conditional knockoutpiggyBactransgenictransposon

Identifiers

PMID42433665
PMCPMC13351448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.