ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2026
Where antibiotic time-outs work: department- and ward-stratified effects of a pharmacist-led anti-MRSA time-out.
Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Objective: To assess the impact of a pharmacist-led anti-methicillin-resistant Design: Single-center before-after interrupted time-series study. Setting: An 813-bed tertiary hospital in Tokyo, Japan. Patients: Inpatients receiving intravenous anti-MRSA agents. Methods: Stewardship pharmacists alerted physicians to reassess intravenous anti-MRSA therapy at 72 hours after its start. Monthly days of therapy per 1,000 patient-days (DOT) were compared between October 2017 to September 2022 and October 2022 to September 2024 after stratification by ward and department. Acceptance rate and therapeutic drug monitoring (TDM) tests were also assessed. Results: Hospital-wide DOT showed an immediate non-significant decrease (-19.23; 95% confidence interval [CI] -59.17 to 20.72; Conclusions: Targeting an implementation to areas most likely to benefit from it may improve antimicrobial stewardship when resources are limited. Complementary strategies may be needed if acceptance is poor.
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