ArticleCase reports in ophthalmological medicine2026
Metastatic Malignant Melanoma Masquerading as Tolosa-Hunt Syndrome.
Article in Case reports in ophthalmological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Metastatic Malignant Melanoma Masquerading as Tolosa-Hunt Syndrome.Case reports in ophthalmological medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This case report discusses cavernous sinus metastases arising from uveal melanoma, which manifested after a 7-year remission period. The diagnosis of systemic metastatic disease was made based on ocular symptoms. To our knowledge, this is the second reported case of metastatic uveal melanoma to the cavernous sinus. The initial presentation posed challenges as it resembled Tolosa-Hunt syndrome, supported by neuroimaging and response to steroid treatment. Initially, suspicion of malignancy was low due to the 7-year remission period with no ocular or systemic signs suggestive of metastasis. However, repeat imaging was performed due to worsening symptoms upon tapering of steroid treatment. Subsequently, a biopsy was obtained which confirmed the diagnosis. Case Presentation: A 76-year-old male with a history of left eye choroidal melanoma treated 7 years earlier and achieving complete remission on subsequent follow-ups presented with worsening pain, diplopia, and left ophthalmoplegia upon tapering steroids. An initial MRI suggested Tolosa-Hunt syndrome. A follow-up MRI revealed enlargement of the left cavernous sinus with enhancing soft tissue, extending into the orbital fissures and foramen rotundum. A left orbital-zygomatic craniotomy biopsy confirmed malignant melanoma metastasis originating from the choroidal melanoma. Conclusion: This case underscores the challenge of overlapping clinical presentations and the potential for delayed recognition of metastatic malignancies in unusual sites. Therefore, it emphasizes the importance of vigilant follow-up and consideration of surgical biopsy, if feasible, to explore alternative causes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.