ArticleQuantitative imaging in medicine and surgery2026
Impact of field number and monitor units per segment on magnetic resonance-guided hypofractionated stereotactic radiotherapy for brain metastases: plan quality, deliverability, and robustness trade-offs.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Magnetic resonance-guided linear accelerators (MR-Linacs) have recently been introduced for radiotherapy of brain metastases (BMs), including hypofractionated stereotactic radiotherapy (HSRT). However, optimal strategies for planning HSRT within MR-guided adaptive workflows remain to be established. This study aimed to evaluate the influence of field number and minimum monitor unit per segment (MU/segment) on plan quality, and robustness of dose calculations in MR-guided HSRT for patients with solitary medium-sized BMs. Methods: This retrospective study included 20 patients who underwent HSRT for solitary medium-sized BMs, receiving a prescription dose of 30 Gy in three fractions. Four intensity-modulated radiotherapy (IMRT) plans were systematically generated for each patient by varying the number of fields (9 Results: All four IMRT configurations provided clinically acceptable plans with similar target coverage and no significant differences in conformity, gradient, or homogeneity indices (all P>0.05). Although some dose parameters for normal brain tissue reached statistical significance (overall P<0.001), absolute differences were minor (≤1 cm Conclusions: The 15FL-IMRT configuration provided an optimal balance among plan quality, deliverability, and robustness of dose calculation, supporting its adoption as the preferred planning approach for MR-guided HSRT in patients with solitary medium-sized BMs.
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