ArticleFrontiers in public health2026
Association between anxious-depression and cognitive function in community-dwelling older adults: a latent class analysis.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Anxiety and depression commonly coexist in later life, yet little is known about the heterogeneous manifestations of anxious-depression symptoms and their cognitive correlates among community-dwelling older adults in China. The purpose of this study is to identify heterogeneous anxious-depression symptom profiles and examine their associations with cognitive function among community-dwelling older adults in China. Methods: A total of 5,116 community-dwelling older adults aged ≥60 years were surveyed. Anxiety and depressive symptoms were assessed using the 7-item Generalized Anxiety Disorder Scale and the 15-item Geriatric Depression Scale, with latent class analysis (LCA) used to identify anxious-depression symptom patterns. Cognitive function was assessed using the brief Community Screening Inventory for Dementia. Multivariable linear regression analyses were performed to examine the associations between anxious-depression phenotypes and cognitive function. Results: LCA identified four anxious-depression symptom profiles: high anxious-depression (7.41%), moderate anxious-depression (8.64%), high depression (13.94%), and low anxious-depression (70.01%). After adjusting for covariates, both anxious-depression and depression-dominant phenotypes were significantly linked to lower cognitive function scores (all Conclusion: Distinct anxious-depression symptom subtypes were identified among community-dwelling older adults. The more pronounced the anxiety and depression symptoms, the poorer the cognitive function. These findings underscore the importance of addressing anxiety and depression in community-based cognitive screening and prevention programs.
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