ArticleFrontiers in public health2026
Dietary diversity, migration experience, and brain volume in middle-aged and older adults in rural Japan: a cross-sectional magnetic resonance imaging study.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To identify lifestyle, social, and health-related factors associated with normalized brain volume (NBV), an imaging marker of brain atrophy, among community-dwelling middle-aged and older adults in a rural Japanese population. Methods: This cross-sectional magnetic resonance imaging (MRI) study was conducted within the Tango Iki-iki (Actively Living) Longevity Study, a longitudinal community-based cohort in rural Kyoto, Japan. Participants who underwent brain MRI following cognitive screening were included. NBV was measured from T1-weighted MRI using SIENAX. Associations between NBV and demographic, lifestyle, social, and health-related factors were evaluated using linear regression analyses. Variables associated with NBV after adjustment for age and sex were further examined in multivariable models. Sensitivity analyses and principal component analysis (PCA) of dietary intake patterns were also performed. Results: A total of 235 participants were included in the MRI analysis. After adjustment for age and sex, higher dietary diversity score (DDS) ( Conclusion: Higher dietary diversity and migration experience were independently associated with greater NBV among middle-aged and older adults in a rural Japanese population.
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