Evidence map›Paper›PMID 42433382›Full record

ArticleFrontiers in immunology2026

Immunological and molecular signatures of carbamazepine-induced maculopapular exanthema.

Kerry A Mullan, Stephanie Davies, Kimberley Teoh, Hayley L Tucker, Jeffrey W Lai, Alison Anderson, Marian Todaro, Ching-Ching Ng, Kheng-Seang Lim, Johannes S Kern and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kerry A Mullan *Department of Biochemistry and Molecular Biology, Infection and Immunity Programs, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Stephanie Davies *Department of Biochemistry and Molecular Biology, Infection and Immunity Programs, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Kimberley TeohDepartment of Biochemistry and Molecular Biology, Infection and Immunity Programs, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Hayley L TuckerDepartment of Biochemistry and Molecular Biology, Infection and Immunity Programs, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Jeffrey W LaiDepartment of Biochemistry and Molecular Biology, Infection and Immunity Programs, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Alison AndersonFaculty of Medicine, The University of Melbourne, Melbourne, VIC, Australia.
Marian TodaroFaculty of Medicine, The University of Melbourne, Melbourne, VIC, Australia.
Ching-Ching NgInstitute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia.
Kheng-Seang LimDivision of Neurology, Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Johannes S KernDepartment of Dermatology, Bayside Health, The Alfred and Department of Immunology, The School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Patrick KwanDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Patricia T IllingDepartment of Biochemistry and Molecular Biology, Infection and Immunity Programs, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Anthony W PurcellDepartment of Biochemistry and Molecular Biology, Infection and Immunity Programs, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Nicole A MifsudDepartment of Biochemistry and Molecular Biology, Infection and Immunity Programs, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous adverse drug reactions to carbamazepine range from mild maculopapular exanthema to life-threatening syndromes such as Stevens-Johnson syndrome/toxic epidermal necrolysis. While the immunological basis for HLA-B*15:02-restricted carbamazepine-induced SJS/TEN has received greater attention, mechanisms underlying mild maculopapular exanthema remain poorly understood. In this study, we examined circulating T-cell immune recognition and transcriptomic signatures in the blood of patients with carbamazepine-induced maculopapular exanthema during active and resolved disease and compared these profiles with severe reactions. Peripheral blood was collected from patients with active (< 9 days post-diagnosis;

Indexed as

AnticonvulsantsCarbamazepineDrug EruptionsExanthemaAdultAgedCytokinesFemaleGene Expression ProfilingHumansMaleMiddle AgedStevens-Johnson SyndromeT-LymphocytesTranscriptomeAnticonvulsantsCarbamazepineCytokinescarbamazepinedrug hypersensitivity reactionmaculopapular exanthemaStevens–Johnson syndromeT-cell receptorT-cellstranscriptomics

Identifiers

PMID42433382
PMCPMC13350515

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.