Evidence map›Paper›PMID 42433371›Full record

ArticleFrontiers in immunology2026

Xylosyltransferase-II deficiency rewires innate immune signaling and destabilizes polarization in human macrophages.

Alina Witt, Thanh-Diep Ly, Matthias Kühle, Cornelius Knabbe, Isabel Faust-Hinse

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alina WittHerz- und Diabeteszentrum Nordrhein-Westfalen, Institut für Laboratoriums- und Transfusionsmedizin, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
Thanh-Diep LyHerz- und Diabeteszentrum Nordrhein-Westfalen, Institut für Laboratoriums- und Transfusionsmedizin, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
Matthias KühleHerz- und Diabeteszentrum Nordrhein-Westfalen, Institut für Laboratoriums- und Transfusionsmedizin, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
Cornelius KnabbeHerz- und Diabeteszentrum Nordrhein-Westfalen, Institut für Laboratoriums- und Transfusionsmedizin, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
Isabel Faust-HinseHerz- und Diabeteszentrum Nordrhein-Westfalen, Institut für Laboratoriums- und Transfusionsmedizin, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xylosyltransferase-II (XT-II), encoded by

Indexed as

Immunity, InnateMacrophagesPentosyltransferasesSignal TransductionCell PolarityCells, CulturedCytokinesHumansMacrophage ActivationUDP Xylose-Protein XylosyltransferaseCytokinesPentosyltransferasesUDP Xylose-Protein XylosyltransferaseinflammationmacrophagesNF-κBosteoclastpolarizationspondylo-ocular syndromexylosyltransferase-II

Identifiers

PMID42433371
PMCPMC13349761

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.