ArticleFrontiers in immunology2026
Clinical significance of radiological usual interstitial pneumonia pattern in primary Sjögren syndrome-associated interstitial lung disease.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- IFN-γ-Associated Signaling Networks in Interstitial Lung Disease Associated With Sjögren's Disease.Immunity, inflammation and disease · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The radiological usual interstitial pneumonia (UIP) pattern demonstrates heterogeneity across different underlying etiologies. This study aimed to characterize its clinical and prognostic impact in primary Sjögren's syndrome-associated interstitial lung disease (pSS-ILD) and compare these features with those in idiopathic pulmonary fibrosis (IPF). Methods: Consecutive patients with pSS-ILD and IPF were enrolled. Clinical characteristics were compared between pSS-ILD patients with (UIP-pSS) and without (non-UIP-pSS) radiological UIP, as well as between UIP-pSS and IPF patients. Risk factors for UIP pattern were identified by logistic regression. Survival was compared using log-rank test. Results: In total, 558 pSS-ILD patients and 199 IPF patients were included. Radiological UIP pattern was identified in 18.8% of the pSS-ILD cohort. Compared to non-UIP-pSS patients, UIP-pSS patients were older, comprised more male patients and smokers (all p<0.05), and showed a greater prevalence of pulmonary hypertension (37.1% vs 20.5%, p=0.003). They also exhibited lower lung diffusing capacity for carbon monoxide (DLco) % predicted (p=0.043), increased composite physiologic index (CPI; p=0.016), and higher Gender-Age-Physiology (GAP) index (p=0.002). Also, UIP-pSS patients had increased 1-year (16.2% vs 6.8%, p=0.002), 3-year (34.4% vs 17.7%, p=0.001), and 5-year mortality (55.7% vs 35.0%, p=0.002). When compared to IPF controls, UIP-pSS patients demonstrated higher DLco % predicted (p<0.001), lower CPI (p=0.009) and GAP index (p<0.001), and longer median survival (66.0 vs 40.0 months, p<0.001). Conclusions: The radiological UIP pattern correlated with impaired pulmonary function and increased mortality in pSS-ILD. However, compared to IPF patients, individuals with UIP-pSS exhibited better pulmonary function and prognosis.
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