ArticleFrontiers in immunology2026
Immunosuppression after pediatric liver transplantation may lead to early and prolonged acute thymic involution: findings from a pilot longitudinal study.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Thymopoiesis plays a critical role in shaping the peripheral T-cell repertoire during childhood. Following pediatric liver transplantation, patients receive intensive immunosuppressive therapy, which may disrupt thymic function; however, thymic involvement after solid organ transplantation remains poorly understood. This prospective study aimed to assess the impact of immunosuppressive therapy on thymic function and morphology in pediatric first-time liver transplant recipients over a one-year follow-up period. The primary endpoint was thymic output, quantified by sjTRECs. Secondary endpoints included intrathymic proliferation (sj/βTREC ratio), recent thymic emigrants (RTEs; CD3
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