ArticleTranslational lung cancer research2026
The impact of local tumor immune responses on prognosis in resected lung adenocarcinoma.
Article in Translational lung cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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14 authors.
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Abstract
Background: Tertiary lymphoid structures (TLS) have been identified in the tumor microenvironment and are increasingly recognized as playing a critical role in local antitumor immune responses. The recurrence-preventive effects observed with perioperative immune checkpoint inhibitors (ICIs) suggest that the immune status of patients undergoing lung cancer resection may significantly influence prognosis. This study analyzed the associations between prognosis and immune cell composition within TLS, including CD8 Methods: This study included 100 patients with lung adenocarcinoma who underwent surgical resection at our institution between January 2018 and January 2019. Representative tumor tissue sections from each case were subjected to multiplex immunofluorescence staining using antibodies against CD8, CD4, CD20, MECA-79, and cytokeratin. The numbers of immune cells within TLS, including CD8 Results: Univariate analysis showed that TLS area, HEV area, CD4 Conclusions: In patients with resected lung adenocarcinoma, TLS area is an independent favorable prognostic factor, and TLS formation is associated with improved clinical outcomes. A significant correlation exists between TLS area and HEV area.
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