ArticleScandinavian journal of medicine & science in sports2026
Persistent Human Quadriceps Muscle Volume Deficits Following ACL Reconstruction Are Associated With No Detectable Between-Leg Differences in Vastus Lateralis Muscle Signaling at Rest or Immediately Following Resistance Exercise.
Article in Scandinavian journal of medicine & science in sports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Quadriceps muscle deficits following anterior cruciate ligament (ACL) injury can persist years beyond reconstruction (ACLR), but the underlying molecular mechanisms remain largely unexplored. This study investigated whether persistent muscle deficits following ACLR are associated with defects in hypertrophic signaling pathways in response to acute resistance exercise. Twelve participants (7 females, 5 males; age 26.7 ± 4.1 years; 2.6 ± 1.5 years post-ACL injury) underwent MRI scanning and one-repetition maximum (1RM) testing to determine muscle volume and unilateral leg-press strength in the ACLR versus contralateral control leg. Following a standardized meal and overnight fast, participants performed unilateral leg-press resistance exercise (6 sets of 8 repetitions at 80% 1RM). Vastus lateralis (VL) muscle biopsies were collected from both legs at rest and immediately post-exercise. Immunoblotting assessed phosphorylation status and total protein content of hypertrophic signaling proteins (e.g., mTORC1 pathway). Total knee extensor muscle volume (7.5% deficit; p = 0.037), VL (7.7% deficit; p = 0.031), and rectus femoris (5.8% deficit; p = 0.022) muscle volumes were decreased in the ACLR versus contralateral control leg. Knee extensor (R
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