Red blood cell deformation in a microfluidic sudden expansion at supraphysiological strain rates.

Hannah P Palahnuk, Nicolas A Tobin, Keefe B Manning

Abstract read

In one paragraph

Article in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hannah P PalahnukDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA; Applied Research Laboratory, The Pennsylvania State University, University Park, PA, USA.

Nicolas A TobinApplied Research Laboratory, The Pennsylvania State University, University Park, PA, USA.

Keefe B ManningDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA; Department of Surgery, Penn State College of Medicine, Hershey, PA, USA. Electronic address: kbm10@psu.edu.

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025

$33.7M

NCATS NIH HHS UL1 TR002014

6 · The paper itself

Abstract

Red blood cell (RBC) deformability is critical for in vivo tissue oxygenation and has been studied in ideal, canonical flows. In vitro frameworks are needed to study RBC deformation in more complex flows than those studied previously, as complex hemodynamics are common in blood-wetted medical devices and valvular pathologies. In this study, pseudo-three-dimensional RBC deformation and orientation angles are investigated in vitro in a microfluidic sudden expansion under two viscosity conditions (2.05 and 4.17 cP) and three flow rates (100, 200, and 400 μL/min). The velocity gradient in the sudden expansion is supraphysiological (3,000-200,000 s

Indexed as

Erythrocyte DeformabilityErythrocytesMicrofluidic Analytical TechniquesMicrofluidicsStress, MechanicalHumansViscosity

Identifiers

PMID42433024

DOI10.1016/j.bpj.2026.07.009

PMCPMC13472205

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.