Evidence map›Paper›PMID 42432793›Full record

Observational studyCritical care (London, England)2026

Echocardiographic assessment of left ventricular longitudinal function in critically ill patients.

Oscar Cavefors, Odd Bech-Hanssen, Björn Redfors, Jonatan Oras

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03787810 (Left Ventricular Dysfunction in Critically Ill Patients), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03787810 completednot on this map

Left Ventricular Dysfunction in Critically Ill Patients

TypeobservationalSponsorSahlgrenska University HospitalRan2018 to 2020Enrolled428ConditionsLeft Ventricular Dysfunction, Critically Ill, Acute Coronary Syndrome, CardiomyopathiesArmsEchocardiography
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Oscar CaveforsDepartment of Anaesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. oscar.cavefors@vgregion.se.
Odd Bech-HanssenDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Björn RedforsDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jonatan OrasDepartment of Anaesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the intensive care unit (ICU), conventional assessment of left ventricular systolic function relies on left ventricular ejection fraction (LVEF), but LVEF often has limited prognostic ability. Measures of longitudinal LV performance [global longitudinal strain (GLS), mitral annular plane systolic excursion (MAPSE), and tissue Doppler-derived systolic velocity (S')] are increasingly used in critical care echocardiography and may capture clinically relevant dysfunction better than LVEF. To date, the prognostic implications of GLS, MAPSE, and S' have been studied mainly in septic cohorts, while their feasibility and prognostic value in mixed ICU populations remain uncertain. We therefore aimed to evaluate the feasibility and prognostic value of these parameters in a mixed ICU cohort.

methodsIn this exploratory secondary analysis of a prospective observational ICU cohort, transthoracic echocardiography was performed within 24 hours of ICU admission. LVEF by Simpson biplane, GLS, MAPSE, and S' were analysed offline. Feasibility was quantified as the proportion of patients with analysable measurements. Associations between echocardiographic parameters were assessed using simple linear regression and are reported as coefficients of determination (R

resultsOf 411 enrolled patients, 377 had at least one parameter available and were included. Feasibility was 71% for LVEF, 65% for GLS, 90% for MAPSE, and 83% for S'. GLS correlated most strongly with LVEF (R

conclusionsIn a mixed ICU cohort, impaired MAPSE and GLS were associated with increased mortality, in contrast to LVEF and S'. MAPSE was also the most feasible measurement. Incorporation of MAPSE into routine ICU echocardiography may improve detection and risk stratification of LV dysfunction in critical illness.

trial registrationSecondary analysis of data from a single-centre prospective observational study focused on systolic dysfunction in ICU patients (Clinical Trials ID: NCT03787810).

Indexed as

EchocardiographyVentricular Function, LeftAgedCohort StudiesCritical IllnessFemaleGlobal Longitudinal StrainHumansIntensive Care UnitsMaleMiddle AgedPrognosisProspective StudiesStroke VolumeVentricular Dysfunction, Left

Identifiers

PMID42432793
PMCPMC13352900

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Registered trials

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