Evidence map›Paper›PMID 42432780›Full record

ArticleActa neuropathologica communications2026

Matrix metalloprotease-9 modulates microglial/macrophage responses in murine brain demyelination.

Eline Bernaerts, Amber De Visscher, Sam Vanherle, Marie Rutten, Fran Prenen, Nele Berghmans, Jana Van Broeckhoven, Hanne Meers, Mirre De Bondt, Febe Boudry and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Eline BernaertsLaboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium.
Amber De VisscherLaboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium.
Sam VanherleDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, 3590, Diepenbeek, Belgium.
Marie RuttenDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, 3590, Diepenbeek, Belgium.
Fran PrenenLaboratory of Immunoparasitology, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium.
Nele BerghmansLaboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium.
Jana Van BroeckhovenDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, 3590, Diepenbeek, Belgium.
Hanne MeersLaboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium.
Mirre De BondtDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, 3590, Diepenbeek, Belgium.
Febe BoudryDepartment of Microbiology, Immunology and Transplantation, KU Leuven Campus Kulak, 8500, Kortrijk, Belgium.
Sofie KnoopsLaboratory of Immunoparasitology, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium.
Tania MiteraLaboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium.
Lien De SomerLaboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium.
Jeroen BogieDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, 3590, Diepenbeek, Belgium.
Patrick MatthysLaboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium.
Jennifer VandoorenLaboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium. Jennifer.vandooren@kuleuven.be.

Funding

Fondation Charcot 2020, 2021Fondation Charcot CHARCO23SVFonds Wetenschappelijk Onderzoek 1192221NFonds Wetenschappelijk Onderzoek 11H9123N and 11H9125NFonds Wetenschappelijk Onderzoek 11K0722N and 11K0724NFonds Wetenschappelijk Onderzoek 1246724NFonds Wetenschappelijk Onderzoek G075823, G0A3B24Fonds Wetenschappelijk Onderzoek G0A5Q25NGSKE GSKE-BOGJGSKE GSKEVHES26KU Leuven STG/23/059MS liga Vlaanderen MSLIGABOGJ
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disorder, in which the immune system targets the protective myelin sheath surrounding axons in the brain, spinal cord and optic nerve, leading to demyelination and ultimately neurodegeneration. Promoting remyelination to delay or halt disease progression remains a major therapeutic challenge in MS research. Matrix metalloproteases (MMPs) have been implicated in the pathogenesis of MS. Elevated levels of MMP-9 have been detected in cerebrospinal fluid (CSF), serum and demyelinating lesions of MS patients, where MMP-9 contributes to myelin breakdown, epitope generation, and leukocyte infiltration. In the in vivo experimental autoimmune encephalomyelitis and lysophosphatidylcholine (LPC) murine MS models, Mmp9

Indexed as

BrainDemyelinating DiseasesMacrophagesMatrix Metalloproteinase 9MicrogliaAnimalsCuprizoneDisease Models, AnimalFemaleLysophosphatidylcholinesMiceMice, Inbred C57BLMice, KnockoutMyelin SheathRemyelinationCuprizoneLysophosphatidylcholinesMatrix Metalloproteinase 9Mmp9 protein, mouseCuprizone-induced demyelination modelInflammationLysophosphatidylcholine modelMicrogliaMMP-9ProteolysisResolution

Identifiers

PMID42432780
PMCPMC13637125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.