Evidence map›Paper›PMID 42432773›Full record

SynthesisSystematic reviews2026

Grading the evidence for CPET variables in predicting perioperative morbidity and long-term mortality in lung cancer surgery: a systematic review and meta-analysis.

Yaoshan Dun, Jialin Yu, Yang Gao, Randal J Thomas, Ray W Squires, Thomas P Olson, Wenliang Zhang, Shaoping Wu, Yang Du, Suixin Liu

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Systematic reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yaoshan DunDivision of Cardiac Rehabilitation, Department of Physical Medicine & Rehabilitation, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China.ORCID http://orcid.org/0000-0001-8642-9024
Jialin YuDivision of Cardiac Rehabilitation, Department of Physical Medicine & Rehabilitation, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China.
Yang GaoNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Randal J ThomasDivision of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Ray W SquiresDivision of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Thomas P OlsonDivision of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Wenliang ZhangDivision of Cardiac Rehabilitation, Department of Physical Medicine & Rehabilitation, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China.
Shaoping WuDivision of Cardiac Rehabilitation, Department of Physical Medicine & Rehabilitation, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China.
Yang DuNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Suixin LiuDivision of Cardiac Rehabilitation, Department of Physical Medicine & Rehabilitation, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China. liusuixin@csu.edu.cn.

Funding

GanPo Talents Program-Leading Talents in Innovation gpyc20250228Health Research Project of Hunan Provincial Health Commission 20257661National Natural Science Foundation of China 82272613National Natural Science Foundation of China 82372576Natural Science Foundation of Hunan Province 2022JJ40777
6 · The paper itself

Abstract

objectiveCurrent cardiopulmonary exercise testing (CPET) guidelines for lung cancer surgery rely on expert consensus and scientific statements, lacking robust, graded evidence. This study aimed to provide an evidence-based evaluation of CPET variables for assessing perioperative morbidity and long-term mortality risks.

methodsElectronic databases were searched through December 20, 2025, for cohort studies on CPET variables and lung cancer surgery. Quality was assessed using the Newcastle-Ottawa Scale. Heterogeneity was evaluated by the Q-test and I

resultsOf 3080 studies, 47 studies involving 11,356 surgeries and 13 CPET variables were included. Meta-analysis and GRADE assessment showed lower peak oxygen uptake (peak

conclusionAmong 13 CPET variables, only peak SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42023405083.

Indexed as

Exercise TestLung NeoplasmsPostoperative ComplicationsHumansOxygen ConsumptionAll-cause mortalityCardiopulmonary exercise testingLung cancerPeakPerioperative complicationsPrognosisSurgery

Identifiers

PMID42432773
PMCPMC13640234

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.