ArticleVeterinary research2026
Hemolysin EthA is an Edwardsiella T3SS effector that induces PANoptosis in macrophages.
Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Edwardsiella piscicida is an enteric intracellular bacterial pathogen. It has been reported that this bacterium produces two types of hemolysins: the secreted, pore-forming toxin HlyA and the cell-associated toxin EthA. EthA has been reported to enter epithelial cells by binding to outer membrane vesicles (OMVs) and that once inside the host cells, it releases lipopolysaccharide from the OMVs to induce pyroptosis. We report here the existence of another pathway by which EthA is secreted and delivered into host cells: the type III secretion system (T3SS) of E. piscicida. The ΔFur box-P
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