ArticleOrphanet journal of rare diseases2026
Total glucosides of Paeony alleviates chronic endometritis in rats through regulating gut microbiota composition and inhibiting TLR4/NF-κB/NLRP3 pathway.
Article in Orphanet journal of rare diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveThis study aimed to elucidate the functional role and regulating mechanism of Total Glucosides of Paeony (TGP) in chronic endometritis (CE).
methodsTo assess the impact of TGP on CE, a CE rat model was established via infusion with 60 µL of 5.0 mg/mL LPS, while human endometrial stromal cells (HESCs) were pre-treated with 500 ng/mL LPS to simulate a CE cell model. Cell proliferation and apoptosis were evaluated using CCK-8, Flow cytometry and EDU staining techniques. Histological changes in uterine tissues were evaluated using H&E staining, while NLRP3 expression was analyzed via IHC staining. Levels of TNF-α, IL-1β, IL-6, and IL-10 in tissues were determined using enzyme-linked immunosorbent assay (ELISA). Additionally, the impact of TGP on intestinal flora was investigated using 16S rRNA sequencing.
resultsTGP treatment attenuated pathological changes in uterine structure and inflammatory response in CE rats. It effectively suppressed the activation of the TLR4/NF-κB/NLRP3 pathway in CE rats. Moreover, TGP significantly enhanced the diversity and richness of intestinal microbiota in CE rats. The CE cell model further validated that TGP suppressed inflammation in LPS-induced HESCs.
conclusionTGP demonstrates beneficial effects on LPS-induced chronic endometritis in rats through modulating the composition of intestinal microbiota and inhibition of TLR4/NF-κB/NLRP3 pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.