Evidence map›Paper›PMID 42432668›Full record

ReviewBMC veterinary research2026

Advances in paratuberculosis research and control: a comprehensive expert review.

R Arrazuria, M Alonso-Hearn, R A Juste, A Facciuolo, A P Koets, H Köhler, R Guatteo, I R Grant, K Plain, C G Mc Aloon and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

R ArrazuriaAnimal Science Department, NEIKER-BRTA- Basque Institute for Agricultural Research and Development, Derio, Spain. rakel.arrazuria@neiker.eus.
M Alonso-HearnAnimal Science Department, NEIKER-BRTA- Basque Institute for Agricultural Research and Development, Derio, Spain.
R A JusteAnimal Science Department, NEIKER-BRTA- Basque Institute for Agricultural Research and Development, Derio, Spain.
A FacciuoloVaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.
A P KoetsWageningen Bioveterinary Research (WBVR), Lelystad, The Netherlands.
H KöhlerFriedrich-Loeffler-Institut, Jena, Germany.
R GuatteoOniris, INRAE, BIOEPAR, Nantes, France.
I R GrantSchool of Biological Sciences, Queens University Belfast, Belfast, Northern Ireland, UK.
K PlainElizabeth Macarthur Agricultural Institute, Menangle, Australia.
C G Mc AloonCentre for Veterinary Epidemiology and Risk Analysis, School of Veterinary Medicine, University College Dublin, Dublin, Ireland.
D GrahamCentre for Veterinary Epidemiology and Risk Analysis, School of Veterinary Medicine, University College Dublin, Dublin, Ireland.
C VerdugoInstituto de Medicina Preventiva Veterinaria, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile.
M RicchiIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Diagnostic Section of Piacenza, Gariga, Italy.
S L MundoUniversidad de Buenos Aires, Buenos Aires, Argentina.
N ElguezabalAnimal Science Department, NEIKER-BRTA- Basque Institute for Agricultural Research and Development, Derio, Spain. nelguezabal@neiker.eus.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review summarizes the 2025 update of the DISCONTOOLS gap analysis for Paratuberculosis, which was based on scientific literature review combined with expert knowledge. It summarizes recent advances across key areas including diagnostics, epidemiology, pathogenesis, vaccination, genetic resistance and alternative therapies. Progress in understanding host-pathogen interactions and immune responses is highlighted alongside developments in diagnostic tools such as molecular assays and phage-based detection. Vaccination strategies continue to evolve with efforts to improve efficacy and reduce interference with bovine Tuberculosis testing. Genetic studies reveal certain heritability of resistance traits, supporting breeding programs as complementary control measures. Alternative therapies including antibodies, mycobacteriophages, and probiotics show promise for early-life infection management. This review also addresses potential public health implications mostly related to the association with Crohn's disease. Despite advances, significant knowledge gaps persist, emphasizing the need for advanced control strategies or therapies to effectively manage Paratuberculosis in ruminants.

Indexed as

ParatuberculosisAnimalsCattleMycobacterium avium subsp. paratuberculosisRuminantsVaccinationControlDiagnosisJohne’s diseaseParatuberculosisRuminants

Identifiers

PMID42432668
PMCPMC13647809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.