ArticleBMC pediatrics2026
Association of Aggregate Index of Systemic Inflammation (AISI) with all-cause mortality in critically Ill pediatric patients: a retrospective cohort study.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
backgroundGrowing evidence supports the prognostic utility of AISI in adults, but its association with mortality in the critically ill pediatric population remains poorly characterized.
objectiveTo investigate the association between AISI and 28-day all-cause mortality in critically ill pediatric patients.
methodsA total of 8,797 patients admitted to the pediatric intensive care unit were included from the PIC Database. The AISI was log₂-transformed and categorized into four groups based on quartiles. The outcomes included 28-day all-cause mortality, both in-hospital and in-ICU. Cox proportional hazards regression, restricted cubic spline, two-piecewise threshold model, and subgroup analyses were used to evaluate the association between AISI and 28-day all-cause mortality.
resultsMales accounted for 4,930 (56.0%) of the patients. The overall 28-day in-hospital and ICU all-cause mortality rates were 4.3% and 4.2%, respectively. The RCS analysis revealed a significant nonlinear association between the log
conclusionsThis study suggests a nonlinear association between AISI and 28-day mortality in critically ill pediatric patients. AISI levels above the threshold were independently associated with an increased mortality risk.
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