Evidence map›Paper›PMID 42432574›Full record

ArticleBMC surgery2026

Efficacy of circumferential surgery for multisegmental pyogenic cervical spine infection.

Shuang Xu, Shuai Zhang, ZiYao Ma, Qing Wang, Song Wang

Abstract read
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Article in BMC surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Shuang Xu *Department of Spine Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.
Shuai Zhang *Department of Spine Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.
ZiYao MaSouthwest Medical University, Luzhou, Sichuan, China.
Qing WangDepartment of Spine Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.
Song WangDepartment of Spine Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China. Jasewangspine@swmu.edu.cn.

Funding

Natural Science Foundation of Sichuan Province NO.2023NSFSC0333Research Program of the Affiliated Hospital of Southwest Medical University NO.24066Sichuan Science and Technology Program NO.2022-YFS0628
6 · The paper itself

Abstract

objectiveTo evaluate the efficacy of circumferential surgery, involving combined anterior and posterior approaches, in the management of multisegmental cervical pyogenic spondylitis (CPS).

methodsA retrospective analysis was conducted on 12 patients with multisegmental CPS who underwent circumferential surgical intervention between January 2015 and November 2023. The study evaluated medical records, spinal alignment correction, postoperative complications, and neurological functional recovery.

resultsIn total, 12 patients (8 men and 4 women; mean age: 57.1 years) met the inclusion criteria. Identified risk factors included diabetes mellitus in four patients, a history of substance abuse in two patients, and long-term immunosuppressive therapy following organ transplantation in one patient. Preoperatively, nine patients presented with spinal cord or nerve root compression. All patients underwent circumferential surgery with anterior column reconstruction using autologous bone grafts; titanium alloy plates were additionally used in two cases. Posterior stabilization was achieved using pedicle screws or lateral mass screws. The mean number of corpectomies performed was 3.7 (range, 3-5); the mean number of fused levels was 4.8 (range, 4-7). The mean follow-up duration was 19.4 (range, 6-38) months. Cervical alignment improved significantly, with the mean C2-7 Cobb angle changing from - 5° preoperatively to 3° postoperatively. Neurological function significantly improved in all patients (P = 0.023), and successful bone fusion was achieved in 11 patients (91.7%) at the final follow-up. Pathogens were identified in seven cases, including Staphylococcus aureus Staphylococcus epidermidis (n = 2), Klebsiella pneumoniae (n = 1), and Escherichia coli (n = 1). All patients received intravenous antibiotic therapy for 4-6 weeks postoperatively, followed by oral antibiotic treatment for an additional 6-8 weeks. No intraoperative complications were reported. Postoperatively, one patient developed pneumonia with respiratory failure, and another experienced posterior cervical wound infection.

conclusionsCircumferential surgical intervention combined with appropriate antibiotic therapy appears to be an effective treatment strategy for achieving satisfactory outcomes in patients with multisegmental CPS.

Indexed as

Cervical VertebraeSpondylitisAdultAgedBone TransplantationFemaleHumansMaleMiddle AgedRetrospective StudiesSpinal FusionTreatment OutcomeAnterior debridementCervicalPosterior fixationPyogenic spondylitis

Identifiers

PMID42432574
PMCPMC13640263

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.