Evidence map›Paper›PMID 42432468›Full record

ArticleJournal of the American Heart Association2026

Mind, Mood, and Mobility: Rethinking Functional Disability Prevention in Older Adults on the Basis of a Longitudinal Cohort From CHARLS.

Lijie Ding, Ruth Stephen, Maria Ekblom, Hui Xin Wang, Emerald G Heiland, Rui Wang

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lijie Ding *Division of Health Management, School of Sport Social Science Shandong Sport University Shandong China.ORCID 0000-0002-9041-9045
Ruth Stephen *Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden.ORCID 0000-0002-3380-9530
Maria EkblomDepartment of Health Sciences The Swedish School of Sport and Health Sciences, GIH Stockholm Sweden.ORCID 0000-0002-7879-9188
Hui Xin WangDepartment of Psychology, Stress Research Institute Stockholm University Stockholm 106 91 Sweden.ORCID 0000-0002-5051-4929
Emerald G HeilandDepartment of Health Sciences The Swedish School of Sport and Health Sciences, GIH Stockholm Sweden.ORCID 0000-0001-7175-0093
Rui WangDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden.ORCID 0000-0001-7209-741X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisability among older adults in China is becoming an increasing public health challenge due to rapid population aging. We aim to investigate how cognitive deficits, depression, and physical function limitation jointly contribute to the onset and progression of disability.

methodsWe included 4226 individuals aged ≥60 years from the China Health and Retirement Longitudinal Study, who were followed for a mean of 7.8 years (2010-2020). Physical function, cognition, and depressive symptoms were assessed. Outcomes included incident activities of daily living (ADL) disability and the number of ADL and instrumental ADL disabilities. Cox regression, linear mixed-effects models, and structural equation modeling were applied.

resultsHaving ≥2 conditions of cognitive deficits, depression, and physical function limitation concurrently at baseline was associated with a higher risk of incident ADL disability (hazard ratio [HR]

conclusionsThe co-occurrence of cognitive deficits, depression, and physical function limitations may synergistically drive long-term disability. Our findings highlight the importance of early screening and holistic management of cognitive, mental, and physical health to reduce the burden of disability in aging populations.

Indexed as

Activities of Daily LivingAffectAgingCognitionCognitive DysfunctionDepressionMobility LimitationPersons with DisabilitiesAgedChinaDisability EvaluationFemaleGeriatric AssessmentHumansLongitudinal StudiesMalecognitive deficitsdepressive symptomsfunctional disabilitymediationphysical performance

Identifiers

PMID42432468
PMCPMC13477323

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.