ArticleJournal of the American Heart Association2026
Association of Inflammatory Markers With Symptomatic Intracranial Hemorrhage, Malignant Cerebral Edema, and Poor Functional Recovery in Patients With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the association of inflammatory markers with the risks of clinical outcomes in patients with acute ischemic stroke and large-vessel occlusion who underwent endovascular thrombectomy treatment.
methodsA total of 586 patients with acute ischemic stroke and large-vessel occlusion treated with endovascular thrombectomy between May 2017 and February 2025 were enrolled. Patients were stratified into quartiles according to inflammatory markers measured within 24 hours after endovascular thrombectomy, including neutrophil count, neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index, systemic immune-inflammation index, inflammatory prognostic index, and aggregate index of systemic inflammation. Logistic regression was used to assess associations between these markers and poor functional outcome (modified Rankin Scale score 3-6) at 90 days, symptomatic intracranial hemorrhage within 24 hours, and malignant cerebral edema within 5 days. Receiver operating characteristic curves evaluated predictive performance.
resultsAfter adjusting for confounders, participants in the highest quartile of each inflammatory marker had significantly higher odds of poor functional recovery (all
conclusionsAll inflammatory markers, particularly the NLR, were independently associated with an increased risk of poor functional recovery, symptomatic intracranial hemorrhage, and malignant cerebral edema in patients with acute ischemic stroke and large-vessel occlusion after endovascular thrombectomy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.