ArticleJournal of the American Heart Association2026
Plasma Apolipoprotein E Levels and Adverse Clinical Outcomes After Ischemic Stroke.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
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Abstract
backgroundApolipoprotein E (ApoE) is implicated in the development of cerebrovascular diseases, but its association with the prognosis of ischemic stroke remains unclear. We aimed to explore the associations between plasma ApoE levels and adverse clinical outcomes after ischemic stroke in a prognostic cohort study.
methodWe measured plasma ApoE levels among 5410 patients with ischemic stroke from the Minhang Stroke Cohort study. The primary outcome was the composite outcome of death and major disability (modified Rankin Scale score=3-6) at 3 months after stroke onset. Secondary outcomes included major disability, death, and the ordered 7-level categorical score of the modified Rankin Scale.
resultsIn the prognostic cohort study, the multivariable adjusted odds ratio associated with the highest quartile of plasma ApoE levels was 1.37 (95% CI=1.10-1.70;
conclusionsHigh plasma ApoE levels were independently associated with increased risk of adverse outcomes among patients with ischemic stroke, suggesting that plasma ApoE might be implicated in the prognosis of ischemic stroke.
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