ArticleAging clinical and experimental research2026
Intrinsic capacity and comorbidity burden capture distinct but age-driven dimensions of health in older postmenopausal women.
Article in Aging clinical and experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIntrinsic capacity (IC) and comorbidity burden are both associated with health outcomes in older postmenopausal women, yet whether they capture independent dimensions of health remains unclear.
aimsTo examine whether comorbidity burden is independently associated with IC in older postmenopausal women, and to evaluate the role of age as a potential confounder of this relationship.
methodsIC was evaluated across five WHO-defined domains using ICOPE-aligned tools, and the number of preserved IC components (range 0-6) was calculated as an index of functional reserve. Comorbidity burden was quantified with the Charlson Comorbidity Index (CCI).
resultsA total of 200 postmenopausal women were included (mean age 68.2 ± 8.5 years, range 46-89). The mean CCI score was 3.5 ± 1.9 and the mean number of preserved IC components was 3.4 ± 1.3. Preserved IC components were inversely correlated with CCI (ρ = -0.33, p < 0.001). In multivariable analysis, CCI was not independently associated with preserved IC (β = -0.036, 95% CI - 0.142 to 0.070, p = 0.505), whereas age was a strong independent predictor (β = -0.078, 95% CI - 0.100 to - 0.055, p < 0.001). The partial correlation between IC and CCI controlling for age was negligible (r = 0.003, p = 0.962). Sensitivity analyses using Poisson regression and a 5-component IC score excluding the vision domain confirmed these findings. CCI was not independently associated with any individual IC domain in domain-specific logistic regression models. DISCUSSION: The observed association between IC and comorbidity burden was largely explained by age, suggesting that these constructs capture overlapping but not identical dimensions of health vulnerability.
conclusionsIC captures dimensions of functional vulnerability not fully accounted for by comorbidity burden alone.
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