SynthesisMycotoxin research2026
Inflammatory response involved in cartilage degeneration induced by T-2 toxin: systematic review.
Synthesis in Mycotoxin research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The aim of our study was to explore the role of inflammatory factors in degenerated articular cartilage exposure to T-2 toxin. The search strings were performed in PubMed database, CBM (Chinese Biomedical Literature Database), EMBASE, Web of Science, Wanfang database and CNKI (Chinese Journal Full Text Database). The random effect model was adopted to analyze the inflammatory markers, interleukin-6 (IL-6), interleukin-1β (IL-1β) ,and tumor necrosis factor-α (TNF-α), of cartilage degeneration induced by T-2 toxin. The differentially expressed genes of cartilage degeneration by T-2 toxin were identified, and the molecular mechanism was observed by Protein-Protein Interaction (PPI) network analysis, Cytoscape, as well as GO functional annotation (GO) and KEGG pathway enrichment analysis (KEGG). his study identified 40 chondrocytes related inflammatory genes from 13 published studies. Among them, the 26 genes were included in the PPI analysis. Gene network analysis revealed that inflammation, extracellular matrix degradation, and apoptosis were involved in the damaged chondrocytes exposed to T-2 toxin. Additionally, IL-6 was identified as a key gene in the Cytoscape analysis. GO and KEGG further demonstrated that these differentially expressed genes were mainly enriched in inflammation- and apoptosis-related pathways, which were closely associated with chondrocyte degeneration processes.Moreover, the levels of IL-6, TNF-α, and IL-1β were significantly higher in the T-2 toxin group than those in control group. Specifically, the significant differences were observed in serum levels of IL-6 (SMD = 3.80, 95% CI: 1.65-5.95, P
Indexed as
Identifiers
42432279What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.