ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
EDI-OCT detection of sub-Tenon's fluid in posterior scleritis in myopic eyes: a retrospective case series.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposePosterior scleritis is an uncommon and difficult to diagnose vision-threatening inflammatory condition, particularly in myopic eyes. This study describes enhanced depth imaging optical coherence tomography (EDI-OCT) features of posterior scleritis in myopic eyes and evaluates the diagnostic value of sub-Tenon's fluid on EDI-OCT.
methodsRetrospective single-centre case series at tertiary eye unit, Moorfields Eye Hospital, UK. Ten myopic eyes of nine patients (spherical refractive error ≤ - 1.00D) diagnosed with posterior scleritis between January 2018 and December 2024 included. Demographics, best-corrected visual acuity (BCVA), clinical features, treatment, and outcomes were recorded. Macular EDI-OCT scans were reviewed for inflammatory changes, including sub-Tenon's fluid, and compared with ultrasound B-scan findings.
resultsMean age at presentation was 55 years (range 24-70), 56% female patients and mean refractive error - 4.45D. Mean presenting BCVA was 6/12, improving to 6/9 after treatment (p = 0.009). Presenting symptoms included ocular pain (80% eyes), blurred vision (50%), optic disc swelling sign (40%). All eyes received systemic corticosteroids and 50% required second-line immunosuppression. EDI-OCT demonstrated sub-Tenon's fluid in 60%, subretinal fluid in 30%, cystoid macular oedema in 20%, and choroidal folds in 40%. Sub-Tenon's fluid correlated with the ultrasound T-sign (κ = 0.78; 95% CI 0.39-1.00; p = 0.011; 90% agreement). EDI-OCT abnormalities resolved in 80% of eyes at three months. Mean sub-foveal choroidal thickness was 307 μm and was not correlated with refractive error.
conclusionsSub-Tenon's fluid on EDI-OCT may represent a useful biomarker for posterior scleritis in myopic eyes and a non-invasive adjunct for diagnosis and monitoring.
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