Evidence map›Paper›PMID 42432135›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Utility of FDG PET/CT for detection of infective endocarditis in pediatric and young adult congenital heart disease.

Matthew Cleveland, Hyeonseon Kim, Jason Gillum, Laura Drubach, Kathryn Beaulieu, Vicky Kourmouzi, Erin Keenan, Douglas Mah, Neha Kwatra, Stephan D Voss

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Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthew ClevelandDepartment of Radiology, Joint Program in Nuclear Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hyeonseon KimDepartment of Radiology, Joint Program in Nuclear Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jason GillumDepartment of Radiology, Joint Program in Nuclear Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Laura DrubachDepartment of Radiology, Division of Nuclear Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
Kathryn BeaulieuDepartment of Radiology, Division of Nuclear Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
Vicky KourmouziDepartment of Radiology, Division of Nuclear Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
Erin KeenanClinical Nutrition, Boston Children's Hospital, Boston, MA, USA.
Douglas MahDepartment of Cardiology, Division of Electrophysiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Neha KwatraDepartment of Radiology, Division of Nuclear Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
Stephan D VossDepartment of Radiology, Division of Nuclear Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA. stephan.voss@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-2092-2219

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCongenital heart disease (CHD) patients are at increased risk of developing infective endocarditis, particularly following placement of prosthetic valves, stents, and vascular conduits. As compared to studies of infective endocarditis in adults, there is limited data on use of FDG PET/CT for evaluation of pediatric CHD patients. The primary aim of this study is to determine the value of FDG PET/CT for detecting infective endocarditis in a cohort of pediatric and young adult patients with complex CHD, with a secondary aim of demonstrating the feasibility of obtaining adequate dietary preparation in these complex patients.

methodsSingle center retrospective review of patients undergoing

results67 patients accounted for the 75 examinations meeting inclusion criteria. Median age was 21 (IQR 15-26) years. The most common underlying diagnosis was Tetralogy of Fallot (n = 27). Implanted devices were present in 62/67 patients; 53/67 patients had more than 1 implanted device. RV/PA conduit (n = 48) and Melody valve (n = 27) were the most common implants. 50 of 75 (67%) examinations were positive by FDG PET/CT criteria. Sensitivity was 95.9%; specificity was 88.5%, with an overall accuracy of 93.3%. 73% of examinations had adequate suppression of myocardial FDG uptake.

conclusions

Indexed as

EndocarditisFluorodeoxyglucose F18Heart Defects, CongenitalPositron Emission Tomography Computed TomographyAdolescentAdultChildFemaleHumansMaleRetrospective StudiesYoung AdultFluorodeoxyglucose F18Congenital heart diseaseDuke criteriaEndocarditisFDG PET/CTKetogenic diet

Identifiers

PMID42432135

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.